RE: Cl/F and V/F

From: Jogarao V Gobburu Date: July 29, 2002 technical Source: cognigencorp.com
From:"Gobburu, Jogarao V" Subject:RE: [NMusers] Cl/F and V/F Date:Mon, 29 Jul 2002 17:14:41 -0400 Dear Paul, 1. You do not have to multiply the CL and V for F1. It is already taken care of. Although, I am sure you realize that they are still apparent parameter values. The adjustment you have for F1 is only relative, not absolute (unless your formulation #1 is iv). 2. You do not need the first conditional: IF(FORM.EQ.1) TVF1=THETA(1). My understanding from your email is that your reference is formulation#1, which will be TVF1=1. Regards, Joga Gobburu, Pharmacometrics, CDER, FDA

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Jul 29, 2002 Paul Hutson Cl/F and V/F
Jul 29, 2002 Jogarao V Gobburu RE: Cl/F and V/F
Jul 29, 2002 Nick Holford Re: Cl/F and V/F
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