RE: Metabolite kinetics help

From:"Sam Liao" Subject:RE: [NMusers] Metabolite kinetics help Date:Mon, 1 Jul 2002 17:34:21 -0400 Hi Peter: When I tried this model in simulation mode, the metabolite concentrations predicted were in the order of 10E-4, There could be some problems in your model specification causing the ERROR IN LSODI1. If the metabolite has the same concentration unit as the parent drug, S3 should be like this S1 = V1/1000 S3 = 1/1000 Also check the FM initial estimate. The initial estimates of EPS(1) and EPS(2) seems to be too large. However, this may not be the cause of ERROR IN LSODI1. Best regards, Sam Liao, Ph.D. PharMax Research 270 Kerry Lane, Blue Bell, PA 19422 phone: 215-6541151 efax: 1-720-2946783