Enterohepatic Circulation!!!
From: "Vanapalli, Sreenivasa"
Subject:[NMusers] Enterohepatic Circulation!!!
Date:Fri, 31 May 2002 13:16:50 -0700
Hello
I'm trying to model a second peak after oral administration. It looks like
enterohepatic circulation. Can someone suggest me if I'm doing right?
I ran the following model. But output is not showing any second peak. Is
there anything I need to modify the Data file?
Thanks
Sreenivasa Rao Vanapalli, Ph.D.
$PROBLEM
$INPUT ID DOSE=AMT TIME DV CMT EVID MDV
$DATA
$SUBROUTINES ADVAN6 TOL=5
$MODEL NCOMPARTMENTS=6 COMP=(DEPOT, DEFDOSE) COMP=(CENTRAL, DEFOBS)
COMP=(PERI)
COMP=(ENT) COMP=(DUMMY1) COMP=(DUMMY2)
$PK (LAGGED)
CALLFL=-2
KA=THETA(1)
CL=THETA(2)*EXP(ETA(1))
VC=THETA(3)*EXP(ETA(2))
VP=THETA(4)
Q=THETA(5)
FENT=THETA(6)
ALAG5=THETA(7)
ALAG6=ALAG5+THETA(8)
K24=THETA(9)
K42=THETA(10)
K23=Q/VC
K32=Q/VP
KEL=CL/VC
IF (NEWIND.LT.2) THEN
EHYN=0
OLDTIM=0
ENDIF
IF (OLDTIM.EQ.ALAG5) EHYN=1
IF (OLDTIM.EQ.ALAG6) EHYN=0
$DES
DADT(1)=-KA*A(1)
DADT(2)=KA*A(1)-(1-FENT)*KEL*A(2)-K23*A(2)+K32*A(3)-FENT*K24*A(2)+EHYN*K42*A
(4)
DADT(3)=K23*A(2)-K32*A(3)
DADT(4)=FENT*K24*A(2)-EHYN*K42*A(4)
DADT(5)=0
DADT(6)=0
$THETA
$OMEGA
$ERROR
DEL=0
IF (F.EQ.0) DEL=1
W=F+DEL
Y=F*(1+ERR(1))+ERR(2)
IPRED=F
IRES=DV-IPRED
IWRES=IRES/W
$SIGMA
Sreenivasa Rao Vanapalli, Ph.D.
Scientist, Pharmacology,
Theravance Inc.,
South San Francisco, CA-94080
Phone: 650-808-6454
Fax : 650-808-6441