"Tip of the Week #11 - May 24 , 2002" - Solution to NONMEM Coding Challenge #2

From:"Bachman, William" Subject:[NMusers] "Tip of the Week #11 - May 24 , 2002" - Solution to NONMEM Coding Challenge #2 Date:Fri, 24 May 2002 09:29:33 -0400 In a previous tip of the week, "Tip of the Week #8 - Sequential numbering in a NONMEM TABLE" we gave code for generating sequential ID's (SID), record numbers within an individual (INDR) and overall sequential record numbers (INDX)): $PK ;TO SEQUENTIALLY NUMBER INDIVIDUALS IF(NEWIND.EQ.0) SID=1 IF(NEWIND.EQ.1) SID=SID+1 ;TO NUMBER RECORDS WITHIN AN INDIVIDUAL IF(NEWIND.EQ.1.OR.NEWIND.EQ.0) INDR=1 IF(NEWIND.EQ.2) INDR=INDR+1 ;TO NUMBER ALL RECORDS IN A DATAFILE IF(NEWIND.EQ.0) INDX=1 IF(NEWIND.EQ.1.OR.NEWIND.EQ.2) INDX=INDX+1 ... $ESTIMATION MAXEVAL=9999 PRINT=5 METHOD=0 ;DON'T USE POSTHOC or FOCE!!! $TABLE ID TIME DV AMT SID INDR INDX FILE=TABLE.TAB NOPRINT We also issued the following caveat and challenge - NONMEM Coding Challenge #2: 1. Why doesn't this code generate the correct values for SID & INDX with Posthoc or FOCE? NONMEM may make more than one "pass" when values from from the data records are copied for tables and scatterplots. The reserved variable COMACT is set by NONMEM and may be tested to determine when NONMEM is making a copying pass. COMACT=0: This is not a copying pass. COMACT=1: This is a copying pass with final thetas; etas are zero. COMACT=2: This is a copying pass with final thetas and conditional etas. In the case where POSTHOC or FOCE is used, more than one pass will be made resulting in incorrect values for SID and INDX in the above code. See NONMEM Users Guide VIII, pages 133-134 for more information. 2. How would you code a general method that works for M=0/M=0 Posthoc/M=1? Send your solutions to nmconsult@globomaxnm.com. Best solution will appear as a future tip of the week. The solution to the challenge was suggested by none other than Professor Beal! $PK ; IF (COMACT.EQ.1) THEN ;use this line for FO IF (COMACT.EQ.2) THEN ;use this line for FO POSTHOC or FOCE ;TO SEQUENTIALLY NUMBER INDIVIDUALS IF (NEWIND.EQ.0) SID=0 IF (NEWIND.LT.2) SID=SID+1 ;TO NUMBER ALL RECORDS IN A DATAFILE IF(NEWIND.EQ.0) INDX=1 IF(NEWIND.GT.0) INDX=INDX+1 ENDIF ;TO NUMBER RECORDS WITHIN AN INDIVIDUAL IF(NEWIND.LT.2) INDR=1 IF(NEWIND.EQ.2) INDR=INDR+1 ... $EST MAXEVAL=9999 PRINT=5 METHOD=1 $TABLE ID TIME DV AMT SID INDR INDX FILE=TABLE.TAB NOPRINT Previous tips may be found in the NONMEM Repository@GloboMax: ftp://ftp.globomaxnm.com/Public/nonmem/tips/ ***************************************************************** If you have a "tip" or a better way to do things, by all means, feel free to post them! One of the reasons for doing this (other than good PR for GloboMax), is to stimulate discussion. We at GloboMax can learn from your experience as well. Do you have a "tip" you would like to share, but would prefer to remain anonymous? If so, you may forward it to us and your identity will be withheld. Distribution as a "Tip of the Week" will be at the discretion of nmconsult@globomaxnm.com. ***************************************************************** nmconsult@globomaxnm.com GloboMax LLC 7250 Parkway Drive, Suite 430 Hanover, MD 21076 Voice: (410) 782-2205 FAX: (410) 712-0737