nonmem

From: Sabine Wittemer Subject: [NMusers] nonmem Date: Mon, 22 Apr 2002 11:50:10 -0700 Dear Sir, I'm a PhD student from Germany and I just start learning something about POPPk and Nonmem. As I was looking at the internet about this topic I found your adress. As this is a very complex topic you maybe can help me with the follwing question. What is the impact of two different ways (linear vs. power) that are used to evaluate the effect of weight on clearance with respect to change in the objective function, diagnostic plots and parameter estimation. It would be very kind if you answer this question or give some advise for suitable literature. Thank you for your cooparation Sabine Wittemer