RE: Approximate effect compartment

From: "Bachman, William" Subject: RE: [NMusers] Approximate effect compartment Date: Fri, 22 Mar 2002 07:39:27 -0500 Daren, What you are proposing sounds like a lot of "hassle" to me. Why not just simultaneously fit all of your data from all routes of administration, particularly because the newer data is sparse. Just fit it all using an extravascular dosing model (e.g. ADVAN12). The original IV data (dense?) will stabilize the model and allow calculation of absolute F of the intranasal formulation. Am I missing something here? (seems to be a straight forward approach). Bill William J. Bachman, Ph.D. GloboMax LLC 7250 Parkway Dr., Suite 430 Hanover, MD 21076 Voice (410) 782-2212 FAX (410) 712-0737 bachmanw@globomax.com