RE: Concentration dependent volume of distribution
From: Piotrovskij, Vladimir [PRDBE] [mailto:VPIOTROV@PRDBE.jnj.com]
Subject: RE: [NMusers] Concentration dependent volume of distribution
Date: Tuesday, March 19, 2002 5:04 AM
Johan,
I don't think making V explicitly dependent on conc of amount is a right way to follow.
If V is concentration-dependent it indicates nonlinear distribution caused by, eg, saturable
protein binding. You'd better explore nonlinear binding in the central or peripheral compartment,
or, alternatively, a saturable transport to (one of the) peripheral compartments, etc.
Best regards,
Vladimir