RE: Parallel absorption model (two lag times)
From:"Sam Liao"
Subject:RE: [NMusers] Parallel absorption model (two lag times)
Date:Sun, February 3, 2002 8:58 pm
Hi Atul:
Try to use the bioavailability fraction F1, and F2 instead.
These are additional PK paramaters you can define in your PK model.
for example:
CL=TVCL*EXP(ETA(1))
V=TVV*EXP(ETA(2))
K12=TVK12*EXP(ETA(3))
K21=TVK21*EXP(ETA(4))
ALAG1=TALAG1*EXP(ETA(5))
ALAG2=TALAG2*EXP(ETA(6))
KA=TVKA*EXP(ETA(7))
F1=TVB1*EXP(ETA(8))
KB=TVKB*EXP(ETA(9))
F2=1-F1
S3=V/1000
Best regards,
Sam Liao, Ph.D.
PharMax Research
270 Kerry Lane,
Blue Bell, PA 19422
phone: 215-6541151
efax: 1-720-2946783