RE: Error: Initial Values for ATOL / LSODI1 CODE 205 ?

From:"Piotrovskij, Vladimir [PRDBE]" Subject:RE: [NMusers] Error: Initial Values for ATOL / LSODI1 CODE 205 ? Date:Mon, February 11, 2002 3:56 am Title: RE: [NMusers] Error: Initial Values for ATOL / LSODI1 CODE 205 ? Kyun-Seop, ERROR IN LSODI1: CODE 205 or 204 means DES does not feel comfortable with your model and/or (initial) parameter values. I think your model is not fully correct as it returns negative A(5): the first error I got when I ran your code "as is" was run-time error M6201: MATH - log: DOMAIN error When I fixed PH = 7 in your $DES block and ran $SIMULATION ONLY (OMEGA and SIGMA fixed to 0) I got the message ERROR IN LSODI1: CODE 205. After playing with initial values I found that with $THETA (0, 0.5) ;THETA(2), VMAX - Is my initial guesses not adequate? (0, .2) ;THETA(3), KM (0, 0.01) ;THETA(4), KGE $SIMULATION can be done. Examining As revealed A(5)<0. It seems you have to check the model. Best regards, Vladimir ----------------------------------------------------------------- Vladimir Piotrovsky, Ph.D. Research Fellow, Advanced PK-PD Modeling & Simulation Global Clinical Pharmacokinetics and Clinical Pharmacology (ext. 5463/151) Johnson & Johnson Pharmaceutical Research & Development Turnhoutseweg 30 B-2340 Beerse Belgium Fax: (+3214) 605834 Email: vpiotrov@prdbe.jnj.com