error models log domain

From:"Joern Loetsch" Subject:[NMusers] error models log domain Date:Mon, January 28, 2002 12:57 pm Dear nonmem users, what error model could be used for fitting in the log domain when the simple proportional Y=LOG(F)+EPS(1) appears to result in a tendency of underestimation of higher plasma concentrations. Thank you in advance J. lotsch ____________________________________________ Jorn Lotsch, MD pharmazentrum frankfurt, Dept. of Clinical Pharmacology Johann Wolfgang Goethe-University Hospital Theodor-Stern-Kai 7 D-60590 Frankfurt am Main GERMANY Tel.:+49-69-6301-4589 Fax.:+49-69-6301-7636