Re: NONMEM crash?

From:Nick Holford Subject:Re: [NMusers] NONMEM crash? Date:Thu, 24 Jan 2002 1:22 pm I agree with Bill that this is not likely to be simply due to the Win98 version of DOS. I have used NONMEM from the DOS prompt interface extensively on Win98, Win2K and for a couple of months on WinXP. I do not recall a blue screen of death being triggered by using NONMEM from the DOS prompt. Win98 is more prone (than Win2K, WinXP) to problems arising from using system resources (memory, number of tasks running, etc). Both VNM and network software will use system resources in addition to those required by DOS (and the Fortran compiler and NONMEM). Its not clear to me why using ADVAN7 and covariates for PK parameters would cause this kind of crash. As I understand it the NONMEM executable uses very similar system resources irrespective of model complexity. The compiler/linker may need more resources for more complex user defined code and the NONMEM executable may be a bit bigger but the additional resources required to use VNM (especially for the 'visual' windowing) when connected to the network would seem a more likely culprit. Bottom line: Run the ADVAN7 from the DOS prompt and see what happens. Nick PS A new version (301) of Wings for NONMEM has been released. You may want to try this as an alternative for running NONMEM from the DOS prompt. See http://wfn.sourceforge.net/