Re: local minimum

From: Jian-Feng Lu <jianfeng@gene.com> Subject: Re: [NMusers] local minimum Date: Fri, 21 Dec 2001 09:06:41 -0800 Milly, You may use grid search to overcome your problem. The approach is very simple, just set your initial value of CL (for example) as (10,,100) instead of (0,35). "10" is the low bound of CL and "100" is the high bound of CL. NONMEM will find optimal initial value by itself from range 10 to 100. Hope this would overcome the problem of local minimum. Jianfeng -- Jianfeng Lu, Ph.D Pharmacometrics Division of Clinical & Experimental Pharmacology Genentech Inc, 1 DNA Way, MS 70 South San Francisco, CA 94080 tel: (650) 225-5876 fax: (650) 225-6452