Re: Michaelis Menten kinetics

From: David_Bourne <david@boomer.org> Subject: Re: [NMusers] Michaelis Menten kinetics Date: Thu, 29 Nov 2001 10:26:23 -0600 >Dear NONMEM users: >I have a question about Michaelis Menten Kinetics. According to >NONMEM Users Guide-Part VIII p.321, the unit of Km can be amount. Is >that reasonable? It is probably because NONMEM uses drug amount in mg internally when calculating differential equation solutions. Thus the equation is... dX/dt = - Vm*X/(Km + X) [or maybe even dC/dt = - Vm*X/V*(Km + X)] Km needs to be in mg to match the units for X. David Bourne