3 compartment nonlinear pharmacokinetics model

From: "Yungwei Hsu" <hsu00013@mc.duke.edu> Subject: [NMusers] 3 compartment nonlinear pharmacokinetics model Date: Tue, 13 Nov 2001 14:57:35 -0500 Dear all, I am trying to model a 3 compartment nonlinear PK model. The drug's elimination rate is concentration-dependent. Increasing concentration decreases the clearance. My experiment is based on a computer controlled infusion program to target plasma concentration at 4 different steady state levels, each level last 40 min. Two pk data were collected in each step and also series of recovery pk data were collected. Could somebody provide me a template of control file to model this problem? Thanks, Yung-Wei Hsu Human Pharmacology Laboratory Duke University Medical Center e-mail: hsu00013@mc.duke.edu