Coadministered drugs (PK-PD)

From: "bvatul" <bvatul@ufl.edu> Subject: Coadministered drugs (PK-PD) Date: Mon, 1 Oct 2001 14:40:49 -0400 Hello All Could somebody advise on this? I am analysing a sparse data set in which two drugs are co-infused. I have the data of the plasma concentrations of the two drugs along with the data of a secondary marker which has a precursor. One of the drugs say A effects the precursor while drug B effects the secondary marker. I have the data of the two markers too. Both the drugs follow a two compartment model (There is no significant effect of drug B on the pharmacokinetics of Drug A). Could you please share your comments on how to code the two drug concentrations in NONMEM. I am trying to use an indirect response model with Smax etc and simultaneously model both the drugs. Thanks in advance Atul Venkatesh Atul Bhattaram Post-doctoral fellow University of Florida