RE: NONMEM conc-reponse analysis for depression
From: "Gibiansky, Ekaterina" <gibianskye@globomax.com>
Subject: RE: NONMEM conc-reponse analysis for depression
Date: Fri, 5 Oct 2001 14:13:56 -0400
Mark,
after trying to find an answer to the same question for antipsychotics, and
after an unsuccessful PopPK/PD (I found no PK/PD or Dose-response
relationship, though there was a difference from placebo) for an
antipsychotic drug, I am not too optimistic. Luc Balant would be a right
person to ask the question. I can also fax you a couple pages of references
from the paper "Use of dose/concentration response data in psychotropic drug
development". This was a presentation at the 1997 COST B1 meeting "Clinical
pharmacology in psychiatry: finding the right dose of psychotropic drugs".
Luc Balant was one of the editors.
Katya