Sequential absorption processes with lag time

From: kmanouil@unmc.edu Subject: Sequential absorption processes with lag time Date: Thu, 4 Oct 2001 11:58:01 -0500 Dear NONMEM users, I read discussion ?modeling fast and slow absorption? back to 1995. Currently, I have similar type of problem. There is one-compartment model with two absorption compartments linked together by zero-order rate. A drug dosed in one of depot compartments. Absorption from the second compartment had delay in a time. So far I used ADVAN6 with two depot compartments and central compartment. Despite, the fact that the problem was solved with WinNonlin, I cannot figure out how to code time delay in NONMEM. Can you help me with advice? Konstantine Manouilov Research Associate University of Nebraska Medical Center