Re: LOG..

From: Luann Phillips <luann.phillips@cognigencorp.com> Subject: Re: LOG.. Date: Wed, 19 Sep 2001 11:35:27 -0400 I have used LOG in NONMEM frequently so I'm curious about how you're using it and what error messages you are receiving. I know that NONMEM will accept Y=LOG(F). However, some platforms (depending on the FORTRAN compiler and its options) will terminate the run when F=0 (which frequently happens on the first dose record) because LOG(0) = negative infinity. To prevent termination of a run because F=0 for dose records, you can try the following: IF(AMT.NE.0) TPRED=F+1 ;dose record IF(AMT.EQ.0) TPRED=F ;event record Y = TPRED + ESP(1) Luann Phillips Cognigen Corporation Manager of Pharmacometrics R&D 395 Youngs Rd. Williamsville, NY 14221 email: Luann.Phillips@cognigencorp.com Voice: (716) 633-3463 ext. 236 Fax: (716) 633-7404