RE: Help: oral and ig bioavailability by NONMEM

From: Vladimir Piotrovskij Date: August 28, 2001 technical Source: cognigencorp.com
From: "Piotrovskij, Vladimir [JanBe]" <VPIOTROV@janbe.jnj.com> Subject: RE: Help: oral and ig bioavailability by NONMEM Date: Tue, 28 Aug 2001 12:37:24 +0200 Weijiang, I agree with Rik: THETA(9) seems to be redundant. Another potential problem: too few individuals. You cannot estimate so many random effects having only 6 subjects. Fixed effect estimates can also be affected. I think you have to fit each subject separately. Interoccasion variability should be taken into account, too. Best regards, Vladimir Centre for Human Drug Research (CHDR) Zernikedreef 10, 2333CL Leiden, Netherlands tel +31 (0) 71 5246417; fax +31 (0) 71 5246499 email rs@chdr.nl <mailto:rs@chdr.nl> ; http://www.chdr.nl http://www.chdr.nl

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Aug 28, 2001 Weijiang Zhang Help: oral and ig bioavailability by NONMEM
Aug 28, 2001 Rik Schoemaker Re: Help: oral and ig bioavailability by NONMEM
Aug 28, 2001 Vladimir Piotrovskij RE: Help: oral and ig bioavailability by NONMEM
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