Re: NONMEM random number generator

From: Nick Holford <n.holford@auckland.ac.nz> Subject: Re: NONMEM random number generator Date: Tue, 21 Aug 2001 09:17:34 +1200 Stuart, I wonder if you would please expand on 2 things you raise here: 1. Why do you think that RNG issues are not important for *PK simulations*? I suspect the question was more than just PK models but in connection with clinical trial simulations which may have a PK model as just one of components with a stochastic element requiring a RNG. 2. What is the criterion you use for judging the "level with which randomness is truly obtained" and thus deciding whether the RNG properties are adequate for the task? Thanks, Nick -- Nick Holford, Divn Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x6730 fax:373-7556 http://www.phm.auckland.ac.nz/Staff/NHolford/nholford.htm