MSDOS versus VisualNM

From: Partha Nandy Date: August 16, 2001 technical Source: cognigencorp.com
From: "Nandy, Partha" <Partha.Nandy@pharma.com> Subject: MSDOS versus VisualNM Date: Thu, 16 Aug 2001 10:07:12 -0400 Hi Everyone, We have recently installed VISUAL NM and I am running into some problems. I was running a ADVAN2 TRAN 2 on a Dell Pentium 3 machine and got Min OBJ Function of 1694 with the following estimates for Cl, V and Ka (Cl = 78.7 V=705 and Ka=0.296). Recently I tried running the same program and data file using Visual NM and got very very different results. The Min OBJ Function was 1982 and Cl, V and Ka were 25000, 672, and 0.277, respectively. Needless to say that the parameter estimates were not only off, the predictions are way off as well. Can someone suggest how to rectify this problem or what might be the source of this problem? Thanks in advance for all your help. Partha PARTHA NANDY PKDM Tel: (914)709-2205 Fax.: (914)709-2534 E-mail: Partha.Nandy@pharma.com
Aug 16, 2001 Partha Nandy MSDOS versus VisualNM
Aug 16, 2001 William Bachman RE: MSDOS versus VisualNM & NONMEM installation
Aug 16, 2001 Nick Holford Re: MSDOS versus VisualNM