RE: Slow Gradient Method.

From: William Bachman Date: May 30, 2001 technical Source: cognigencorp.com
From: "Bachman, William" <bachmanw@globomax.com> Subject: RE: Slow Gradient Method. Date: Wed, 30 May 2001 07:55:14 -0400 Vladimir, You are correct that this idea is not documented. There are essentially two ways NONMEM obtains gradients needed for performing the pseudo-Newton minimization. One involves only numerical derivatives, the other involves a combination of analytical and numerical derivatives. As you might imagine, the first is often slower than the second. It is therefore used less often. It is used when NUMERICAL is specified. nmconsult@globomax.com GloboMax LLC 7250 Parkway Drive, Suite 430 Hanover, MD 21076 Voice: (410) 782-2205 FAX: (410) 712-0737

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May 24, 2001 Matt Hutmacher Slow Gradient Method.
May 25, 2001 Niclas Jonsson Re: Slow Gradient Method.
May 28, 2001 Vladimir Piotrovskij RE: Slow Gradient Method.
May 28, 2001 Nick Holford Re: Slow Gradient Method.
May 30, 2001 William Bachman RE: Slow Gradient Method.
May 30, 2001 Vladimir Piotrovskij RE: Slow Gradient Method.
May 30, 2001 Stephen Duffull RE: Slow Gradient Method.
May 31, 2001 Niclas Jonsson RE: Slow Gradient Method.
May 31, 2001 Erik Olofsen RE: Slow Gradient Method.
May 31, 2001 Nick Holford Re: Slow Gradient Method.
May 31, 2001 Niclas Jonsson Re: Slow Gradient Method.
May 31, 2001 Stuart Slow Gradient Method
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