RE: Autoinduction
From: "Ziad Hussein" <zhussein@medeval.com>
Subject: RE: Autoinduction
Date: Tue, 15 May 2001 09:32:58 +0100
Dear Sreenivasa,
Few years ago I have used a model with autoinduction for lamotrigine without the use of differential equation British Journal of Clinical Pharmacology 43: 457-465, 1997. The equation to describe autoinduction is:
TVCL=Theta(1)-Theta(2)*exp(-Theta(3)*Time)
in our case lamotrigine was dosed over 48 weeks. I hope that your data covers at least 2 weeks of dosing to able to model the autoinduction.
Kind regards,
Dr Ziad Hussein
Head of Pharmacokinetics
Medeval Ltd
Skelton House
Manchester Science Park
Lloyd Street North
Manchester, UK
Tel: xx-44-161-226 6525 (Ext 295)