Re: Parameterization!!!

From: Nick Holford <n.holford@auckland.ac.nz> Subject: Re: Parameterization!!! Date: Thu, 10 May 2001 09:07:48 +1200 I agree with Leonid's suggestion. I would also point out that if you do not use a BLOCK to allow correlation between your parameters your model is almost certainly more wrong than usual. I cannot imagine a realistic circumstance where CL and V would not be correlated (e.g. both will increase with increasing body size, or both will increase if F increases if the dose is oral) so always start with a BLOCK and only take it off if your data or other priors inform you that the assumption of no correlation is reasonable. -- Nick Holford, Divn Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x6730 fax:373-7556 http://www.phm.auckland.ac.nz/Staff/NHolford/nholford.htm