constant CV
From: "clement" <clement@ha.mc.ntu.edu.tw>
Subject:constant CV
Date: Thu, 26 Apr 2001 19:21:04 +0800
Hello, nmusers
As a beginner for NONMEM, I wonder would someone kindly told me what's the point to consider in selecting the following parameter or error models. In addition to statistical consideration, is there any physiological meaning for the selection?
(If body weight is a factor to consider)
TVCL = THETA(1)*WT
TVCL= THETA(1)*WT*EXP(THETA(2))
TVCL=THETA(1)*(WT/60)*EXP(THETA(2))
CL=TVCL+ETA(1)
CL=TVCL*(1+ETA(1))
CL=TVCL*EXP(ETA(1))
LOG(CL)=LOG(TVCL)+ETA(1)
Any help will be appreciated.
Clement