NONPAR
From: "michel.tod" <michel.tod@avc.ap-hop-paris.fr>
Subject: NONPAR
Date: Tue, 27 Mar 2001 11:53:53 +0200
Dear NM users,
In the very good paper entitled "Use of a PK/PD model to design an optimal dose input profile" by Kyungsoo Park et al. (JPB 1998, 26, 471-492), there is a rather enigmatic statement (p 480): " ... a discrete nonparametric estimate of the density of eta was used... The option NONPAR in NONMEM provides estimates of the probability mass for each eta(j) ..."
It seems that the option NONPAR is not documented in the users guide (at least I did not found it). Could anyone explain how to use this option and/or provide an example of a control file?
Michel Tod.
Dpt of Pharmacotoxicology
Avicenne Hospital
Bobigny, France