Rounding errors / $SIM superproblem

From: peter.bonate@quintiles.com Subject: Rounding errors / $SIM superproblem Date: Fri, 23 Mar 2001 08:06:11 -0600 I have a few questions over the last couple of months and thought I would pose them to the group. 1.) At what point in the optimization process is NONMEM sensitive to rounding errors and secondly, if minimization is terminated due to rounding errors, can anything else be done except change the starting values. 2.) Can someone explain what a superproblem is and how it relates to the $SIM option. Thanks. pete bonate