Correlations for power analysis

From: Paul Hutson <prhutson@pharmacy.wisc.edu> Subject: Correlations for power analysis Date: Fri, 08 Dec 2000 09:08:21 -0600 Greetings, everyone. I am trying to power a validation study using limited sampling to estimate the AUC (or clearance). We are collecting a full PK set as the gold standard, but are utilizing samples drawn at two pre-determined time points in the Bayesian analysis. What level of correlation or predictive performance would be considered acceptable by this group? I was planning to use the correlation instead of the predictive performance (mpe rmse) in the power / sample size analysis since I am unfamiliar with how to utilize the predictive performance parameters. Does this seem reasonable? Thank you. Paul Hutson, Pharm.D. Associate Professor (CHS) UW School of Pharmacy 425 N. Charter St Madison, WI 53706-1515 Tel: (608) 263-2496 FAX: (608) 265-5421 Pager: (608) 265-7000, #7856