Re: Correct codes of modeling Michaelis-Menten elimination using concentration-time data

From: "Jiannguo Li" <LIJ4@gunet.georgetown.edu> Subject: Re: Correct codes of modeling Michaelis-Menten elimination using concentration-time data Date: Fri, 29 Sep 2000 15:44:03 -0400 Now, we understand that the implicit unit of Vm is always "amount/time" in order to use the code suggested by the help guide. Since the unit of initial estimates of Vm from the Hans-Woolf plot or the Woolf-Augustinsson-Hofstee plot using concentration time data is "amount/(time*volume)", the NM users may need to be reminded to adjust the initial estimates of Vm by the initially selected volume of distribution (V) for the use of the code. Jianguo Li, PhD Center for Drug Development Science Georgetown University