Re: Weight as Covariate

From: Nick Holford <n.holford@auckland.ac.nz> Subject: Re: Weight as Covariate Date: Sat, 23 Sep 2000 18:15:25 +1200 One obvious suggestion is to parameterize your model in terms of CL and V then use WT as a covariate on CL as well as V. It is theoretically absurd to imagine CL does not vary with WT. This may or may not fix your flip-flop problem but at least you will have a sensible description of CL and V. Nick -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x6730 fax:373-7556 http://www.phm.auckland.ac.nz/Staff/NHolford/nholford.htm