Re: test of differences between posthocs

Date: Fri, 28 Jul 2000 08:53:49 -0400 (EDT) From: "Jogarao Gobburu 301-594-5354 FAX 301-480-3212" <GOBBURUJ@cder.fda.gov> Subject: Re: test of differences between posthocs Hello, 1. If you believe that there is autoinduction, treating infusion duration as a covariate will limit the use of the model. It might be more mechanistic to model clearance as concentration dependent. 2. While it is not clear to me, as to the purpose of the whole modeling exercise (probably to prefer one duration over the others rather than deriving optimal duration/input-rate that might not have been studied) - you can use the nonparametric Kolmogorov-Smirnov's test to compare distributions of a test statistic (eg; AUC corrected for dose if necessary) from two populations. If you do have duration as a significant (by some standard) covariate, you probably already know that these groups are different. Regards, Joga Gobburu Pharmacometrics, CDER, FDA.