RE: Inter occasion variability

From: "Stephen Duffull" <sduffull@pharmacy.uq.edu.au> Subject: RE: Inter occasion variability Date: Mon, 28 Feb 2000 09:08:05 +1000 Hi Sriram As I see your problem you could only add IOV to parameters that are common between the placebo and active dose model (if I have read your description properly). For example at the begining of each study period you will presumably model the concentration of cortisol (ie E0) which could then have IOV on it to account for random variability in the baseline cortisol conc. Hempel et al [Clin Pharmacol Ther 1998;64:622-35] did something similar with 24 hour BP control. Regards Steve ================= Stephen Duffull School of Pharmacy University of Queensland Brisbane, QLD 4072 Australia Ph +61 7 3365 8808 Fax +61 7 3365 1688