RE: Drug-metabolite kinetics

From: "Bachman, William" <bachmanw@globomax.com> Subject: RE: Drug-metabolite kinetics Date: Tue, 6 Jul 1999 07:44:37 -0400 The code originally given mostly likely DOES HAVE IDENTIFIABILITY PROBLEMS (see caveat added). However, its intent was mainly didactic -> how to code a parent-metabolite. The details, of course, are dependent on the usual modeling constraints: does it reflect what we know about the drug?, is it "reasonable"?, does the data we have allow identification of defined parameters?, etc. Also, choice of ADVAN 6, 8 or 9 is, in the end, what works for your data and model. Bill William J. Bachman, Ph.D. GloboMax LLC Senior Scientist 7250 Parkway Drive, Suite 430 Hanover, MD 21076 Voice (410) 782-2212 FAX (410) 712-0737 bachmanw@globomax.com