Steady-state equation

From: Vladimir Piotrovskij Date: July 02, 1999 technical Source: cognigencorp.com
From: "Piotrovskij, Vladimir [JanBe]" <VPIOTROV@janbe.jnj.com> Subject: Steady-state equation Date: Fri, 2 Jul 1999 08:20:18 +0200 Dear NONMEM users, I apologise for this non-NONMEM question. For the one-compartment model with equal absorption and elimination rate constants the single-dose profile is given by Cp=FD/V*k*t*exp(-k*t). Is anybody aware of corresponding analytical multiple-dose and steady-state equations? Any references would be appreciated. Please send replies (if any)directly to me to minimise using nmusers' list for the non-relevant question. Thanks in advance, Vladimir ---------------------------------------------------------------------- Vladimir Piotrovsky, Ph.D. Janssen Research Foundation Clinical Pharmacokinetics B-2340 Beerse Belgium Email: vpiotrov@janbe.jnj.com