RE: Modeling of inter study variability (ISV) as a third random effect level
From: "Piotrovskij, Vladimir [JanBe]" <VPIOTROV@janbe.jnj.com>
Subject: RE: Modeling of inter study variability (ISV) as a third random effect level
Date: Tue, 1 Jun 1999 14:11:16 +0200
Dear,
NONMEM is not the best choice for modelling multiple nested random effects.
The new S-PLUS library called nmle version 3.0 is more suitable. It is on beta-testing now and can be downloaded from the following sites:
http://nlme.stat.wisc.edu/Beta
http://cm.bell-labs.com/stat/NLME/Beta
Since it is already the 8th release, it is quite reliable, I believe.
Best regards,
Vladimir
Vladimir Piotrovsky, PhD
Clinical Pharmacokinetics, ext 5463
Janssen Research Foundation
2340 Beerse, Belgium
e-mail: vpiotrov@janbe.jnj.com