Question: Number of ETA and EPS in statistic significance

From: takeshi.tajima@pharma.Novartis.com Date: Wed, 26 May 1999 13:18:22 +0900 Subject: Question: Number of ETA and EPS in statistic significance Dear NONMEM users, Please answer to my question below. ----------------------------------------------------------------- We can statistically evaluate the change of values of object function (OBJ) when the number of THETA is altered. Example, in addition of another THETA, change of more than 3.84 in OBJ is significant. How about the number of ETA and EPS ? Can we peform statistical evaluation using the change of OBJ with an increase or a decrease of the number of ETA and EPS ? ----------------------------------------------------------------- Best regards, Takeshi Tajima Novartis Pharma K.K. Tsukuba Research Institute