Re: flip-flop kinetics

From: "Nick Holford" <n.holford@auckland.ac.nz> Subject: Re: flip-flop kinetics Date: Sat, 3 Apr 1999 09:07:56 +1200 Yes (well at least within the usual caveat of all models being wrong). The closed form solution parameterised in A,alpha,B,beta is obtained by integrating the DEs and hiding the DE parameterisation. The hiding of the parameters is part of the legacy of having mathematicians rather than biologists think about how to express the model. It does not change the solution. However, reparameterisation can change the final solution if the obj function minimum is not well defined because the search depends on the parameterisation. Any differences in the model prediction are usually small. If they are big something is wrong with the way the model is coded or the data is very poor for identifying the model parameters. -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x6730 fax:373-7556 http://www.phm.auckland.ac.nz/Staff/NHolford/nholford.html