RE: How to calculate confidential interval of a plasma conc. curve

From: "Yuen, Geoffrey J" <gjy25826@glaxowellcome.com> Subject: RE: How to calculate confidential interval of a plasma conc. curve Date: Fri, 11 Dec 1998 14:27:50 -0500 Just one comment. In order to do the simulations correctly the full covariance matrix should be used. This is obviously not an issue with performing the simulations in NONMEM. ADAPT II can also perform these simulation using the covariance matrix. Based on what was described for S-plus...I don't believe that the full covariance matrix was used. This implys that the parameter are independent which may not be a correct assumption. Geoffrey Yuen, Pharm.D. Clinical Pharmacokineticist Glaxo-Wellcome 5 Moore Drive RTP, NC 27709 phone 919 483 5676 email gjy25826@glaxowellcome.com