2 compartment MM

From: "Bonate, Peter, HMR/US" <Peter.Bonate@hmrag.com> Subject: 2 compartment MM Date: Fri, 11 Dec 1998 07:10:37 -0600 Speaking of things users should be aware of. If a 2-compartment model with elimination from both the central and peripheral compartments, regardless of whether elimination is linear or nonlinear, is used and only samples are collected from the central compartment, then the parameter estimates will be unidentifiable. Only when samples are collected from both the central and peripheral or metabolite compartment will the parameter estimates be unique and identifiable. PETER L. BONATE, PhD. Population Pharmacokinetics Hoechst Marion Roussel POB 9627 (F4-M3112) Kansas City, MO 64134 phone: 816-966-3723 fax: 816-966-6999