ADVAN 6

From: "Stephen Duffull" <sduffull@fs1.pa.man.ac.uk> Subject: ADVAN 6 Date: Wed, 7 Oct 1998 11:50:20 +0100 I was wondering if anyone could help me with a problem that I seem to run into when using ADVAN6. Briefly, I have 4302 data records. The model I am using has oral/iv dosing with parent and metabolite (both 2 compartment). So with a gut compartment there are a total of 5 compartments. There are 11 parameters (some fixed), 9 etas & 4 epsilons. The problem takes about 2+ days to run (TOL=3). The error that almost always occurs is: NUMERICAL DIFFICULTIES WITH INTEGRATION ROUTINE. MAXIMUM NO. OF EVALUATIONS OF DIFFERENTIAL EQUATIONS, 100000, EXCEEDED. Sometimes it claims to have successfully converged - although when looking at the fits this does not appear to be the case. Any ideas how to get around this one? Steve ============================= Stephen Duffull School of Pharmacy University of Manchester M13 9PL, Manchester, UK Ph +44 161 275 2355 Fax +44 161 275 2396 Email sduffull@fs1.pa.man.ac.uk