Re: Control file

From: alison@c255.ucsf.EDU (ABoeckmann) Subject: Re: Control file Date: 24 Sep 1998 14:08:50 -0400 This question is a bit vague. Here are some general suggestions. I suggest using ADVAN2. In the data, include the CMT data item. A bolus dose to CMT 1 provides first-order input to the central compartment. A infusion dose to CMT 2 provides zero-order input to the central compartment. E.G., $INPUT ID TIME CMT AMT RATE .... In the data: 1 0 1 100 . 1 0 2 50 10 The first dose puts 100 units in cmt 1 at time 0, which then enters cmt 2 in a first-order process with rate constant KA. The second dose is a zero-order input directly into cmt 2, 50 units, at the rate of 10 units per time unit. The example can be made more elaborate. For instance, The dose times need not be the same. There can be multiple doses of both types. It is possible to model the rate or duration of the zero-order dose, by coding the RATE data item as -1 or -2, and then modelling R2 or D2 in the $PK block. Bioavailabilty can be modelled for doses into cmt 1 (F1) or cmt 2 (F2). Either or both doses can be lagged, by modelling ALAG 1 and/or ALAG2. Using F1, F2 and ALAG1 or ALAG2, it is possible to model a combined absorption process in which a single dose has both a zero order and a first order phase, such that two bioavailabilities add to unity.