indirect PK-PD model and lag-time
From: "Hui C. Ko" <koh@compuserve.com>
Subject: indirect PK-PD model and lag-time
Date: 29 Sep 1998 10:31:21 -0400
Dear Silvy and Patrick,
Your NM control;
$DES
DADT(1)=-(K12+K)*A(1) ; PK model 1st cpt
DADT(2)= K12*A(1)-K21*A(2) ; PK model 2nd cpt
EFF=C50/(C50+A(1)/S1)
DADT(3)=KIN*EFF-KOUT*A(3) ; PTR model
needs corrections on;
1. DADT(1) as Alison pointed out,
2. your inhibition function, EFF, should be 1-C50/(C50+A(1)/S1) if you assume Emax is 1.
Hui Ko