RE: Covariate Model Selection II

From: "Piotrovskij, Vladimir" <vpiotrov@janbe.jnj.com> Subject: RE: Covariate Model Selection II Date: 12 Mar 1998 02:59:06 -0500 Dear Peter, There may be no general answer to your question. The situation you describe seems to me extraordinary. However, if you use FO method, it can happen. I personally do not rely on variability parameters estimated by the FO method. FOCE with interaction is much more reliable, but the run time in case of a complex model may become unacceptably long. Best regards, Vladimir ---------------------------------------------------------------------- Vladimir Piotrovsky, Ph.D. Janssen Research Foundation Clinical Pharmacokinetics B-2340 Beerse Belgium Fax: +32-14-605834 Email: vpiotrov@janbe.jnj.com vpiotrov@janbelc1.ssw.jnj.com