Request for help about M-M kinetics

From: alison@c255.ucsf.EDU (ABoeckmann) Subject: Request for help about M-M kinetics Date: 17 Sep 1997 16:15:10 -0400 This is my 3d. attempt at responding to Honghui Zhou's question. Maybe this time I'll get it right. Lew Sheiner spotted the scaling error. Zhou says: The dose is 200 mg, while the unit for DV is ng/mL. In his model: ... S2=THETA(6) $DES C2=A(2)/S2 He is using theta(6) as both the central volume in the computation of C2, and as the scaling term for the predictions. The unit of theta(6) is presumably L, whence C2 is mg/L or mcg/ml. But S2 has the same units, and yet his concentrations are ng/ml, or 1000 times the values that are compatible with his code. He needs something like this: ... V=THETA(6) S2=V/1000 $DES C2=A(2)/V Now predictions are converted from mg/L to mcg/L or ng/mL by the 1000 in S2's denominator. Alison