Any tools for Bayesian estimation?

From MASAKI_HIRAOKA@ccmail.bms.com Thu Mar 13 23:26:33 1997 Subject: Any tools for Bayesian estimation? I attempt to estimate individual eta's from individual measurements using pre-determined theta's, omega's and epsilon's which are obtained by NONMEM methods from a set of data. Does anyone know any application programs for Bayesian estimation that covers the following requirement: 1. Easy modeling: Feasiblility which allows to use any models described using subroutins of ADVAN and TRANS in the NONMEM. 2. Error modeling: Both relative and absolute errors(epsilon's) can be modeled simultaneously. I think it is difficult to understand what two-error-model means, because an estimate for an individual error is only one value that is the difference between observed and estimated concentrations. However, when one estimates using observed values in a wide rage, relative error is suitable for large values and absolute error is for small values near to lower quantitation limit. So, the errors in Bayesian estimation should be evaluate using relative or absolute error models which give preferable likelyhood. 3. Executable on PC with Windows95 Any programs or macros executable directly on PC, using spreadsheet for Windows, or with WinNonlin is preferable. Many thanks, Masaki Hiraoka Kanagawa Laboratories, Bristol-Myers Squibb K.K.