determination of Cmax and formulation effects

From S=Maier%S=Maier%G=Gary%I=A%O=STERLING%OU1=PRD1%KODAK@mcimail.com Thu Aug 17 10:06:40 1995 Subject: determination of Cmax and formulation effects Hello NONMEM users, I have been using NONMEM to determine the relative bioavailability of two different formulations in a population mode. Essentially what was done was to collect all phase I studies in which either or both formulations of interest were administered and then compare that information to a standard two-way cross-over study (n=24). Then 90% confidence intervals were determined for the point estimate of relative F. Advan 4, trans 3 was utilized. Now it is of interest to determine a population estimate of Cmax for each formulation and also calculate a 90% confidence interval. Since Tmax and hence Cmax cannot be determined explicitly, can anyone suggest a sequence of code that can implicitly solve for these two terms so that a theta for formulation can be added and a 90% CI constructed. thank you in advance for your suggestions Gary Maier Sanofi-Winthrop EM GMaier@kodak.com