Buffer Size with Large Data Sets

In some private communication, my attention was called to a recent posting by Ferdie Rombout on the NM Users Net, stating that run times were significantly improved by adjusting the size of NONMEM buffer 1 (see Guide III, p. 21). I would simply like to remind people that, as stated on p.21, as long as the number of data records doesn't exceed 400, adjusting the buffer size will have no effect on run time. Of course, as people become more comfortable with NONMEM, they try larger data sets, and as Dr. Rombout has discovered, with larger data sets, buffer size adjustment can be useful. This is why we hope you will take a little time, during installation time or later, to read about the buffers.